Cardioprotective activity of nelumbo nucifera rhizomes in isoproterenol induced myocardial necrosis in male wistar rats shivendra pratap singh, navneet kumar verma, praveen kumar rai, abhay pratap. Sabir hossain, 1 nadia alam, 4 siew hua gan, 4 and md. Diabetes and isoproterenolinduced myocardial infarction was evident as a. Pdf the present study was designed to investigate the cardioprotective effects of sundarban. Vasodilators may play positive role in myocardial infarction mi. The rats were randomly divided into 4 groups, each group consisting of 8 rats. Isoproterenol iso administration induced the myocardial injury as evidenced by. Original article baicalin ameliorates isoproterenolinduced acute myocardial infarction through inos, inflammation, oxidative stress and p38mapk pathway in rat shenjie sun, xiaopeng wu, hengliang song, guiqi li department of cardiology, the second hospital affiliated to zhengzhou university, zhengzhou 450014, henan, china. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol.
Myocardial infarction was induced by subcutaneous iso administration at a dose of 85 mgkg 1 day 1 with a drug free interval of 24 h on. Research article sundarban honey confers protection. Pdf isoproterenolinduced myocardial infarction in wistar rats. Protective effects of cardamom in isoproterenolinduced myocardial infarction in rats sameer n. Curcumin and curcumin nanoparticles were given by gavage in three di. Antioxidants, fenugreek, isoproterenol, myocardial infarction. Thirty young, male, wistar rats 145 to 230 g were randomly allocated in two groups. In the present study, we investigated whether combination therapy of lowdose benidipine with the potent free radical scavenger edaravone has a cardioprotective effect against isoproterenol isoinduced myocardial infarction mi in wistar rats. Effect of an ethanol extract of embelia ribes fruits on. Protective effects of cardamom in isoproterenolinduced.
Effects of histidine and vitamin c on isoproterenol. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23h corticosterone 3h corticosterone. Effect of cardamom treatment on the activities of sod, cat and gshpx enzymes. The effect of astragaloside iv on isoproterenol induced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. In isoproterenolinduced myocardial damage, the levels of lipid peroxides were increased and gsh, sod and cat. However, the rationale of the combined use remains unclear. A model of myocardial fibrosis and heart failure was established by oncedaily subcutaneous injection of isoproterenol 5 mgkgday to rats for 7 days. Role of nitric oxide in isoprot ernolinduced myocardial infarction 19 during mi are related with nitric oxide formation quantified by the stable products nitrite and nitrates ions. Role of nitric oxide in isoproterenolinduced myocardial. Inadequate blood supply to the heart leads to infarction followed by irreversible necrosis of myocardial tissue. A tool for inducing myocardial infarction in experimental animals, authormohd aftab siddiqui and usama sharif ahmad and ahmed abdullah khan and mohammad ayaz ahmad and badruddeen and mohammad khalid and juber akhtar, year2016. Myocardial infarction, antioxidants, isoproterenol, natural. Keshtkar s, komeili g, keshavarzi f, jahantigh m 2017 cardio protective effects of hydroalcholic citrus aurantium extract on myocardial infarction induced by isoproterenol in male rats. High incidences of myocardial infarction associated with.
Experimental model of myocardial infarction induced by. Shift in antioxidant parameters, lactate dehydrogenase ldh together with morphological and histopathological changes were investigated. However, the effect of ritonavir on cardiac glut4 inhibition during myocardial necrosis is not investigated. Agrawal, 4 santosh kumari, 5 dharamvir singh arya, 2 and shreesh ojha 2, 6. Luteolin a dietary flavonoid attenuates isoproterenol. The present study evaluated cardioprotective effect of lyophilized hydroalcoholic extract of moringa oleifera in the isoproterenol ispinduced model of myocardial infarction. Based on the results presented, we conclude that the model of myocardial infarction induced by isoproterenol in rats was adequately reproduced and validated in our laboratory and caused increased mortality and myocardial injury markers ast and troponin i, reduction of catalase activity and levels of glutathione and histopathological changes. Effect of theobroma cacao polyphenol on isoproterenol. Ischemic tissues generate oxygen derived free radicals which have been implicated in cardiac diseases and metabolic disorder prabhu 2006.
Molecules free fulltext cardioprotective effects of. Pdf the effect of astragaloside iv on isoproterenol. Iso administration is followed by numerous pathophysiology and. We here describe the shortterm effects in rabbit of isoproterenol on the parameters associated with myocardial necrosis histology, ecg, plasma cardiac necrosis markers, or involved in peroxidation vitamin e or coagulation phenomena ptt, in the absence or presence of propranolol or labetalol. Lipid peroxidation was clearl y increased after 696 h of iso treatment as a consequence of ion superoxide formation during the preinfarction period and the nitric. For this,tamoxifen was administered to spraguedawley rats for 114 days, and isoproterenol iso 100 mgkg body mass. The effect of astragaloside iv on isoproterenolinduced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. Protective effect of taurine on myocardial antioxidant status in isoprenalineinduced myocardial infarction in rats. Isoproterenol, is a adrenergic agonist and has been reported to increase lipid peroxidation through enhanced free radical formation4 isoproterenol. Exploration of pharmacological interventions to prevent. Evaluation of cardioprotective effect of tinospora. Amelioration of isoproterenolinduced oxidative damage in.
Although exercise derived activation of nrf2 signaling augments myocardial antioxidant signaling, the molecular mechanisms underlying the benefits of moderate exercise training met in the heart remain elusive. Protective effect of taurine on myocardial antioxidant. Vitamin a is beneficial in counteracting free radical damage, therefore the present study is designed to investigate the effect of vitamin a against isoproterenolinduced myocardial infarction in rats. Cardioprotective activity of nelumbo nucifera rhizomes in. This study aims to investigate the protective effects of kefir against myocardial infarction induced by isoproterenol iso.
Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1. Edaravone, a potent free radical scavenger and a calcium. Isoprenaline isoproterenol is a synthetic catecholamine and. Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenolinduced myocardial infarction in wistar rats. All national and international guidelines for the care and use of animals were closely followed. Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45. Isoproterenolinduced myocardial infarction in albino rats m. Effect of curcuma longa turmeric on serum creatine kinasemb and troponin i in isoproterenol induced myocardial infarction in wistar albino rats. Sham group, which underwent a virtual myocardial infarction induction, and. In the present study, we investigated the effects of histidine and vitamin c alone or in combination treatments against isoproterenol a. In this research, we aim to evaluate the cardioprotective effects of puerarinv on the isoproterenol isoinduced mi mice and elucidate the underlying mechanisms. Wistar albino male rats were divided into three groups and orally fed saline once daily alone sham or with isp isp control or isp with m. We investigated the protective role of withania somnifera leaf extract wslet on isoproterenol iso induced myocardial infarction mi in rats. Pdf evaluation of cardioprotective role of vinpocetine.
Frontiers exercise mediated nrf2 signaling protects the. The isoproterenolinduced myocardial infarction in rodents offers a relevant model to study the effect of natural products. Protective effect of sesamol against myocardial infarction. It is also known to generate free radicals and to stimulate lipid peroxidation, which may. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol iso induced myocardial infarction mi in rats. Frontiers comparative pharmacokinetics of gallic acid. Isoproterenolinduced myocardial infarction in rats. The present study was designed to investigate the cardioprotective effects of paeonol and danshensu representative active ingredient of cortex moutan and radix salviae milthiorrhizae, respectively on isoproterenolinduced myocardial infarction in rats and its underlying mechanisms. Isoproterenollnduced myocardial infarction in rats distribution of corticosterone by jack saroff, ph. Moringa oleifera leaf extract prevents isoproterenol. Gallic acid ga is a polyphenolic natural product widely distributed in food, beverage, and traditional chinese herbs with beneficial effects on the cardiovascular system.
Subcutaneous injection of iso 85 mgkg body weight b. Exploration of pharmacological interventions to prevent isoproterenolinduced myocardial infarction in experimental models show all authors. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23 h corticosterone 3 h corticosterone. In this research, a comparative study was conducted to investigate the possible difference of pharmacokinetic process in normal and isoproterenolinduced myocardial infarcted rats after oral administration of ga monohydrate. Beneficial role of tamoxifen in isoproterenolinduced. Preventive effect of agnucastoside c against isoproterenolinduced myocardial injury. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions.
Here we hypothesized that exercise training stabilizes nrf2dependent antioxidant signaling, which then protects the myocardium from isoproterenolinduced damage. The rats were randomly divided into four groups of 6 rats each. Abstract mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenousl3hy wit corticosteronh 1. However, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Ginsenoside re improves isoproterenolinduced myocardial. As it has been reported that isoproterenol can cause ischemic myocardial alterations, lipid peroxide generation and procoagulant activity, we administered it to rabbits in order to induce a noninvasive myocardial infarction associated with above mentioned. The acute phase of myocardial necrosis induced by isoproterenol mimics changes in blood pressure, heart rate, electrocardiogram ecg, and left ventricular dysfunction similar to that occurring in patients with myocardial infarction. Myocardial infarction is the acute condition of necrosis of the myocardium that occurs as a result of imbalance between coronary blood supply and myocardial demand boudina et al. Cardioprotective effect of fenugreek on isoproterenolinduced.
Preventive effect of agnucastoside c against isoproterenol. Cardioprotective effect of ritonavir, an antiviral drug. Cardioprotective effects of puerarinv on isoproterenol. Aim of the present study, an attempt has been made in acute and chronic periods after isoproterenol isoinduced myocardial infarction mi in male wistar rats. Preventive effect of agnucastoside c against isoproterenolinduced. Pdf effect of curcuma longa turmeric on serum creatine. Isoproterenolinduced myocardial infarction in rats circulation. Free radicals generated by iso initiate lipid peroxidation of the membrane bound polyunsaturated fatty acids, leading to impairment of the. Effect of cardamom on glutathione and lipid peroxidation in the isoproterenolinduced myocardial infarction in rats. Two hundred mgkg iso dose was selected for the present study as this dose. In one experiment effects of the isolated compound at 2.
In the present study, we evaluated the role of ritonavir in isoproterenolinduced. Original article baicalin ameliorates isoproterenol. Myocardial infarction is usually induced in small animals by means of invasive techniques based on mechanical coronary obstruction. Acute treatment with metformin improves cardiac function. Investigation of the protective effect of kefir against. Protective role of black cumin nigella sativa on isoproterenol induced myocardial infarction in rats abstract international journal of pharmacology and clinical sciences, 2012, 1, 2, 4553. Isoproterenol iso, a synthetic catecholamine and adrenergic agonist, has been documented to produce myocardial infarction in large doses rona g.
The present study is designed to evaluate the effect of nigella sativa seeds called black cumin on isoproterenol induced myocardial infarction in experimental rats. Juan carlos torres and gabriela velascoloyden march 28th. Curcumin has antiinflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Buddleja asiatica on isoproterenol induced myocardial necrosis in rats raja sundararajan and ramya. Fiftysix wistarbratislava white rats were randomly divided into eight groups of seven rats each. Vinpocetine is a phosphodiesterase type1 inhibitor having strong vasodilating effect through camp and cgmp elevation. These results clearly show the action of no in isoproterenolinduced myocardial infarction and suggest the importance to assess the role of no in pre infarction and early post infarction stages in patients. Ibrahimkhalil 1,4 laboratory of preventive and integrative biomedicine, department of biochemistry and molecular biology. The isoproterenolinduced myocardial infarction essay in rats. Abstractthis study was designed to investigate the cardioprotective effect of sesamol on isoproterenol isoinduced myocardial infarction in adult male.
Luteolin supplimentated by intragastric intubation at a daily dose of 0. Role of nitric oxide in isoproterenolinduced myocardial infarction. Research article sundarban honey confers protection against isoproterenolinduced myocardial infarction in wistar rats rizwanaafroz, 1,2 e. In addition to its antiviral effect, ritonavir directly inhibits the insulinregulated glucose transporter glut4 and blocks glucose entry into fat and muscle cells. The model is simple in execution and the biochemical, histological and electrocardiographic changes closely mimic that seen in case of an ami. Isoproterenolinduced myocardial infarction in wistar rats rizwana afroz, 1,2 e. On auto oxidation, iso generates highly cytotoxic free radicals known to stimulate peroxidation of membrane phospholipids and cause severe damage to the myocardial membrane. Isoproterenolinduced myocardial infarction in rabbits. Effects of curcumin nanoparticles in isoproterenolinduced.
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